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Lacto-N-tetraose, fucosylation, and secretor status are highly variable in Human Milk Oligosaccharides from women delivering preterm

Author: De Leoz M, Gaerlan S, Strum J, Dimapasoc L, Mirmiran M, Tancredi D, Smilowitz JT, Kalanetrae KM, Millse DA, German JB, Lebrilla CB and Underwood MA. | Journal: Journal of Proteome Research

Volume: 11
Issue: 9
DOI: 10.1021/pr3004979

Background:Breast milk is the ideal nutrition for term infants but must be supplemented to provide adequate growth for most premature infants. Human milk oligosaccharides (HMOs) are remarkably abundant and diverse in breast milk and yet provide no nutritive value to the infant. HMOs appear to have at least two major functions: prebiotic activity (stimulation of the growth of commensal bacteria in the gut) and protection against pathogens. Investigations of HMOs in milk from women delivering preterm have been limited.​​​​​​​
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​​​​​​​ Objective and methods:We present the first detailed mass spectrometric analysis of the fucosylation and sialylation in HMOs in serial specimens of milk from fifteen women delivering preterm and seven women delivering at term using nano-high performance liquid chromatography chip/time-of-flight mass spectrometry. A mixed-effects model with Levene’s test was used for the statistical analyses.​​​​​​​
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​​​​​​​ Results:We find that lacto-N-tetraose, a core HMO, is both more abundant and more highly variable in the milk of women delivering preterm. Furthermore, fucosylation in preterm milk is not as well-regulated as in term milk, resulting in higher within and between mother variation in women delivering preterm vs. term. Of particular clinical interest, the α1,2-linked fucosylated oligosaccharide 2′- fucosyllactose, an indicator of secretor status, is not consistently present across lactation of several mothers that delivered preterm.​​​​​​​
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​​​​​​​ Conclusion:The immaturity of HMO production does not appear to resolve over the time of lactation and may have relevance to the susceptibility of premature infants to necrotizing enterocolitis, late onset sepsis, and related neurodevelopmental impairments. Read More

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