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Do HMOs have any effects on brain development and cognition?

Do HMOs have any effects on brain development and cognition?
Do HMOs have any effects on brain development and cognition?
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References
Do HMOs have any effects on brain development and cognition?

Systemic absorption of HMOs, including 2′FL could indicate their potential role in the development and function of the brain.1,2

  • 2′FL affects cognitive performance and improves learning3 • 2′FL significantly improves the long-term induction and maintenance of the hippocampus4
  • HMO supplementation is associated with improved learning behaviour5, and specific HMOs support behavioural response during stress exposure6
  • Specific HMOs serve as a source of sialic acid for neurological development7

References

    1. Bode L. Human milk oligosaccharides: every baby needs a sugar mama. Glycobiology. 2012 Apr;22(9):1147-62.
    2. Jacobi S, Yatsunenko T, Li D et al. Dietary isomers of sialyllactose increase ganglioside sialic acid concentrations in the corpus callosum and cerebellum and modulate the colonic microbiota of formula-fed piglets. J Nutr. 2015 Dec;146(2):200-8.
    3. Vázquez E, Barranco A, Ramírez M et al. Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents. J Nutr Biochem. 2015 May;26(5):455-65.
    4. Matthies H, Staak S, Krug M. Fucose and fucosyllactose enhance in-vitro hippocampal long-term potentiation. Brain Res. 1996 Jul;725(2):276-80.
    5. Sakai F, Ikeuchi F, Urashima T. Effects of feeding sialyllactose and galactosylated N-acetylneuraminic acid on swimming learning ability and brain lipid composition in adult rats. J Appl Glycosci. 2006;53(4):249-54.
    6. Jacobi S, Yatsunenko T, Li D et al. Dietary isomers of sialyllactose increase ganglioside sialic acid concentrations in the corpus callosum and cerebellum and modulate the colonic microbiota of formula-fed piglets. J Nutr. 2015 Dec;146(2):200-8.
    7. Tarr A, Galley J, Fisher S, Chichlowski M, Berg B, Bailey M. The prebiotics 3′Sialyllactose and 6′Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: evidence for effects on the gut-brain axis. Brain Behav Immun. 2015 Nov;50:166-77.

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